The Moriguchi Route , signed as Route 12, is one of the routes of the Hanshin Expressway system serving the Keihanshin area in Kansai, Japan. It travels in a southwest to northeast direction in Osaka and the neighboring city of Moriguchi, from the Loop Route, in the Kita ward of Osaka, to National Route 1 in the city of Moriguichi. The expressway has a total length of 10.8 kilometers (6.7 mi). It was first opened in 1968, but was completed in 1971.

Moriguchi is a city located in Osaka Prefecture, Japan. As of 31 December 2021, the city had an estimated population of 142,655 in 73353 households and a population density of 11,000 persons per km2. The total area of the city is 12.71 square kilometres (4.91 sq mi).