Morphine was an American rock band formed by Mark Sandman, Dana Colley, and Jerome Deupree in Cambridge, Massachusetts, in 1989. Drummer Billy Conway replaced Deupree as the band's live drummer in 1991. Deupree recorded the album Cure For Pain, with the exception of the title track which was recorded by Conway, before being permanently replaced by Conway in 1993. Both drummers appeared together during a 15 date US tour in March of 1999. After five successful albums and extensive touring, they disbanded after lead vocalist Sandman died of a heart attack onstage in Palestrina, Italy, on July 3, 1999. Founding members have reformed into the band Vapors of Morphine, maintaining much of the original style and sound.

Mark Sandman was an American singer, songwriter, musical instrument inventor, multi-instrumentalist and comic writer. Sandman possessed a distinctive, deep bass-baritone voice and a mysterious demeanour. He was an indie rock icon and longtime fixture in the Boston/Cambridge music scene, best known as the lead singer and slide bass player of the band Morphine. Sandman was also a member of the blues-rock band Treat Her Right and founder of Hi-n-Dry, a recording studio and independent record label.