Morphosis Architects is an interdisciplinary architectural and design practice based in Los Angeles and New York City.

Thom Mayne is an American architect. He is based in Los Angeles. In 1972, Mayne helped found the Southern California Institute of Architecture (SCI-Arc), where he is a trustee and the coordinator of the Design of Cities postgraduate program. Since then he has held teaching positions at SCI-Arc, the California State Polytechnic University, Pomona and the University of California, Los Angeles (UCLA). He is principal of Morphosis Architects, an architectural firm based in Culver City, California and New York City, New York. Mayne received the Pritzker Architecture Prize in March 2005.