The mosaics of Delos are a significant body of ancient Greek mosaic art. Most of the surviving mosaics from Delos, Greece, an island in the Cyclades, date to the last half of the 2nd century BC and early 1st century BC, during the Hellenistic period and beginning of the Roman period of Greece. Hellenistic mosaics were no longer produced after roughly 69 BC, due to warfare with the Kingdom of Pontus and the subsequently abrupt decline of the island's population and position as a major trading center. Among Hellenistic Greek archaeological sites, Delos contains one of the highest concentrations of surviving mosaic artworks. Approximately half of all surviving tessellated Greek mosaics from the Hellenistic period come from Delos.

The Cyclades are an island group in the Aegean Sea, southeast of mainland Greece and a former administrative prefecture of Greece. They are one of the island groups which constitute the Aegean archipelago. The name refers to the archipelago forming a circle around the sacred island of Delos. The largest island of the Cyclades is Naxos, however the most populated is Syros.