The Mosque of Qaytbay, also known as the Madrasa of Qaytbay, is a historic religious structure in the Qal'at al-Kabsh neighbourhood of Cairo, Egypt. Completed in 1475, it is one of multiple monuments sponsored by the Mamluk sultan al-Ashraf Qaytbay. It is not to be confused with the more famous Funerary complex of Qaytbay in the Northern Cemetery. It is described as both a madrasa and a mosque by scholars, but functions as a mosque today.

Sultan Abu Al-Nasr Sayf ad-Din Al-Ashraf Qaitbay was the eighteenth Burji Mamluk Sultan of Egypt from 872 to 901 A.H.. He was Circassian by birth, and was purchased by the ninth sultan Barsbay before being freed by the eleventh Sultan Jaqmaq. During his reign, he stabilized the Mamluk state and economy, consolidated the northern boundaries of the Sultanate with the Ottoman Empire, engaged in trade with other contemporaneous polities, and emerged as a great patron of art and architecture. In fact, although Qaitbay fought sixteen military campaigns, he is best remembered for the spectacular building projects that he sponsored, leaving his mark as an architectural patron on Mecca, Medina, Jerusalem, Damascus, Aleppo, Alexandria, and every quarter of Cairo.