Mosquero is a village in Harding and San Miguel counties in the U.S. state of New Mexico. The population was 93 at the 2010 census, down from 120 in 2000. It is the county seat of Harding County; only a small portion of the village extends into San Miguel County.

Harding County is a county in the U.S. state of New Mexico. As of the 2020 census, the population was 657, making it the least populous county in the state, and the 13th-smallest county by population in the United States. Its county seat is Mosquero. The county is named for United States President Warren G. Harding, and was created on the day of his inauguration as president on March 4, 1921, making him the most recent president to have a county in any state named after him.