"Most Likely You Go Your Way and I'll Go Mine", or "Most Likely You Go Your Way (and I'll Go Mine)", is a song by American singer-songwriter Bob Dylan. It was released as the first track on side three of his seventh studio album Blonde on Blonde (1966). The song was written by Dylan and produced by Bob Johnston. Dylan recounted that he had probably written the song after the end of a relationship. The song's narrator criticizes the lies and weakness of a woman, and says that he finds it hard to care. The final verse establishes that the woman has been unfaithful to the narrator by having a relationship with another man, as he suspected all along.

Blonde on Blonde is the seventh studio album by American singer-songwriter Bob Dylan, released as a double album on June 20, 1966, by Columbia Records. Recording sessions began in New York in October 1965 with numerous backing musicians, including members of Dylan's live backing band, the Hawks. Though sessions continued until January 1966, they yielded only one track that made it onto the final album—"One of Us Must Know ". At producer Bob Johnston's suggestion, Dylan, keyboardist Al Kooper, and guitarist Robbie Robertson moved to the CBS studios in Nashville, Tennessee. These sessions, augmented by some of Nashville's top session musicians, were more fruitful, and in February and March all the remaining songs for the album were recorded.