Major Motoko Kusanagi , or just "Major", is the main protagonist in Masamune Shirow's Ghost in the Shell manga and anime series. She is a synthetic "full-body prosthesis" augmented-cybernetic human employed as the field commander of Public Security Section 9, a fictional anti-cybercrime law-enforcement division of the Japanese National Public Safety Commission. A strong-willed, physically powerful, and highly intelligent cyberhero, she is well known for her skills in deduction, hacking and military tactics.

Ghost in the Shell is a Japanese manga written and illustrated by Masamune Shirow, which spawned the media franchise of the same name. It was first serialized in Kodansha's seinen manga magazine Young Magazine Zōkan Kaizokuban from 1989 to 1991, under the subtitle of The Ghost in the Shell, and was compiled in one tankōbon volume. Set in the mid-21st-century, it tells the story of the fictional counter-cyberterrorist organization Public Security Section 9, led by protagonist Major Motoko Kusanagi.