Many pre-Columbian cultures in North America were collectively termed "Mound Builders", but the term has no formal meaning. It does not refer to specific people or archaeological culture but refers to the characteristic mound earthworks that indigenous peoples erected for an extended period of more than 5,000 years. The "Mound Builder" cultures span the period of roughly 3500 BCE to the 16th century CE, including the Archaic period, Woodland period, and Mississippian period. Geographically, the cultures were present in the region of the Great Lakes, the Ohio River Valley, Florida, and the Mississippi River Valley and its tributary waters.

In the history of the Americas, the pre-Columbian era, also known as the pre-contact era, spans from the original peopling of the Americas in the Upper Paleolithic to European colonization, which began with Christopher Columbus's voyage of 1492. Usually, the era covers the history of Indigenous cultures until significant influence by Europeans. This may have occurred decades or even centuries after Columbus for certain cultures.