Mound City is a city in Holt County, Missouri, United States, centered near the interchange of Interstate 29 and Missouri Route 118. The population was 1,004 at the 2020 census, down from the 1,159 people counted during the previous census.

Holt County is a county located in the northwestern portion of the U.S. state of Missouri. As of the 2020 census, the population was 4,223. It's county seat is Oregon. The county was organized February 15, 1841. Originally named Nodaway County, it was soon renamed for David Rice Holt (1803–1840), a Missouri state legislator from Platte County.