Mount Jefferson is a stratovolcano in the Cascade Volcanic Arc, part of the Cascade Range in the U.S. state of Oregon. The second highest mountain in Oregon, it is situated within Linn County, Jefferson County, and Marion County and forms part of the Mount Jefferson Wilderness. Due to the ruggedness of its surroundings, the mountain is one of the hardest volcanoes to reach in the Cascades. It is also a popular tourist destination despite its remoteness, with recreational activities including hiking, backpacking, mountaineering, and photography. Vegetation at Mount Jefferson is dominated by Douglas fir, silver fir, mountain hemlock, ponderosa pine, lodgepole pine, and several cedar species. Carnivores, insectivores, bats, rodents, deer, birds, and various other species inhabit the area.

The Cascade Volcanoes are a number of volcanoes in a volcanic arc in western North America, extending from southwestern British Columbia through Washington and Oregon to Northern California, a distance of well over 700 miles (1,100 km). The arc formed due to subduction along the Cascadia subduction zone. Although taking its name from the Cascade Range, this term is a geologic grouping rather than a geographic one, and the Cascade Volcanoes extend north into the Coast Mountains, past the Fraser River which is the northward limit of the Cascade Range proper.