Mount Lofty Ranges zone is a wine zone located in South Australia west of the Murray River that occupies the Adelaide metropolitan area north of Glenelg, extending as far north as Crystal Brook, and as far south as Mount Compass in the Mount Lofty Ranges. The zone which encloses the Barossa zone on three sides, includes three wine regions that have received appellation as Australian Geographical Indications (AGIs): Adelaide Hills, Adelaide Plains and Clare Valley. The zone received AGI in 1996.

The Clare Valley wine region is one of Australia's oldest wine regions, best known for Riesling wines. It lies in the Mid North of South Australia, approximately 142 km north of Adelaide. The valley runs north-south, with Horrocks Highway as the main thoroughfare.