Mount Mitchell, known in Cherokee as Attakulla, is the highest peak of the Appalachian Mountains and the highest peak in mainland North America east of the Mississippi River. It is located near Burnsville in Yancey County, North Carolina in the Black Mountain subrange of the Appalachians about 19 miles (31 km) northeast of Asheville. It is protected by Mount Mitchell State Park and surrounded by the Pisgah National Forest. Mount Mitchell's elevation is 6,684 feet (2,037 m) above sea level. Mount Mitchell is ranked 31st by topographic isolation.

The Appalachian Mountains, often called the Appalachians, are a mountain range in eastern to northeastern North America. The term "Appalachian" refers to several different regions associated with the mountain range, and its surrounding terrain. The general definition used is one followed by the United States Geological Survey and the Geological Survey of Canada to describe the respective countries' physiographic regions. The U.S. uses the term Appalachian Highlands and Canada uses the term Appalachian Uplands; the Appalachian Mountains are not synonymous with the Appalachian Plateau, which is one of the provinces of the Appalachian Highlands.