The Mountain Lake Wilderness Cluster is a region recognized by The Wilderness Society for its unique waterfalls, vistas, trout stream and wildlife habitat. The heart of the region is the Mountain Lake Wilderness, the largest wilderness in the George Washington and Jefferson National Forests. These public lands are enhanced by the presence of private lands which are preserved to maintain their natural integrity. The region includes the Mountain Lake Biological Station that studies distinctive wildlife and ecology of the area.

The Craig Creek Cluster is a region recognized by The Wilderness Society for its unique high elevation mountains, vistas, trout streams and wildlife habitat. The cluster contains wildlands and wilderness areas along Craig Creek, a 65-mile long creek with headwaters at the Brush Mountain Wilderness near Blacksburg.