The Mountain Lake Wilderness Cluster is a region recognized by The Wilderness Society for its unique waterfalls, vistas, trout stream and wildlife habitat. The heart of the region is the Mountain Lake Wilderness, the largest wilderness in the George Washington and Jefferson National Forests. These public lands are enhanced by the presence of private lands which are preserved to maintain their natural integrity. The region includes the Mountain Lake Biological Station that studies distinctive wildlife and ecology of the area.

The George Washington and Jefferson National Forests is an administrative entity combining two U.S. National Forests into one of the largest areas of public land in the Eastern United States. The forests cover 1.8 million acres (2,800 sq mi) of land in the Appalachian Mountains of Virginia, West Virginia, and Kentucky. Approximately 1 million acres (1,600 sq mi) of the forest are remote and undeveloped and 139,461 acres (218 sq mi) have been designated as wilderness areas, which prohibits future development.