Mpika is a town in the Muchinga Province of Zambia, lying at the junction of the M1 Road to Kasama and Mbala and the Tanzam Highway to Dar es Salaam, Tanzania in the north-east and Lusaka in the south-west. It also has a railway station on the TAZARA Railway about 5 kilometres (3 mi) away. Mpika is situated between the Muchinga Escarpment to the east and vast miombo plains to the west. The town has an estimated population of 40,000 inhabitants (2008), while the district population is estimated at 150,000 inhabitants. Since Mpika District was the biggest district in Zambia before its division in 2017, the population density was less than 4 people per square kilometre.

Kasama is a city in the Northern Province of Zambia. It serves as the provincial capital and the headquarters of Kasama District.