Mr. Driller Drill Spirits is a 2004 puzzle video game developed and published by Namco for the Nintendo DS. Controlling one of six characters, the player must make it to the bottom of each stage by destroying, colored formations of blocks while preventing their oxygen meter from depleting. Multiple different gamemodes are present, including a single-player campaign, a time-attack mode, and a competitive multiplayer mode. It is the sixth entry in the Mr. Driller series.

The Nintendo DS is a foldable handheld game console produced by Nintendo, released globally across 2004 and 2005. The DS, an initialism for "Developers' System" or "Dual Screen", introduced distinctive new features to handheld games: two LCD screens working in tandem, a built-in microphone and support for wireless connectivity. Both screens are encompassed within a clamshell design similar to the Game Boy Advance SP. The Nintendo DS also features the ability for multiple DS consoles to directly interact with each other over Wi-Fi within a short range without the need to connect to an existing wireless network. Alternatively, they could interact online using the now-defunct Nintendo Wi-Fi Connection service. Its main competitor was Sony's PlayStation Portable during the seventh generation of video game consoles.