Mu'tazilism was an Islamic sect that appeared in early Islamic history and flourished in Basra and Baghdad. Its adherents, the Mu'tazilites, were known for their neutrality in the dispute between Ali and his opponents after the death of the third caliph, Uthman. By the 10th century the term al-muʿtazilah had come to refer to a distinctive Islamic school of speculative theology (kalām). This school of theology was founded by Wasil ibn Ata.

Baghdad is the capital of Iraq and the second-largest city in the Arab world after Cairo. It is located on the Tigris river. In 762 AD, Baghdad was chosen as the capital of the Abbasid Caliphate, and became its most notable major development project. Within a short time, the city evolved into a significant cultural, commercial, and intellectual center of the Muslim world. This, in addition to housing several key academic institutions, including the House of Wisdom, as well as a multi-ethnic and multi-religious environment, garnered it a worldwide reputation as the "Center of Learning".