Muhammad Ahmad Hussein is the incumbent Grand Mufti of Jerusalem. He was appointed in July 2006 by Mahmoud Abbas, the President of the Palestinian National Authority. Abbas raised Hussein as an immediate successor to Ekrima Sa'id Sabri, who was reportedly removed from the position due to his growing popularity amidst his open expressions of highly contentious political views and his condoning of violence in the Israeli–Palestinian conflict.

The Grand Mufti of Jerusalem is the Sunni Muslim cleric in charge of Jerusalem's Islamic holy places, including Al-Aqsa. The position was created by the British military government led by Ronald Storrs in 1918. Since 2006, the position has been held by Muhammad Ahmad Hussein, appointed by the Palestinian President, Mahmoud Abbas.