General Muhammad Musa Khan was a Pakistani senior military officer who served as the 4th Commander-in-Chief of Pakistan Army from 1958 to 1966, under president Ayub Khan. Following his tenure as C-in-C of the Army, he later became a politician.

The Commander-in-Chief of the Pakistan Army was the professional head of the Pakistan Army from 1947 to 1972. The C-in-C was directly responsible for commanding the army. It was an administrative position and the appointment holder had main operational command authority over the army.