Mu'izz ad-Din Muhammad ibn Sam, also known as Muhammad of Ghor or Muhammad Ghori, was a ruler from the Ghurid dynasty based in the Ghor region of what is today central Afghanistan who ruled from 1173 to 1206. Muhammad and his elder brother Ghiyath al-Din Muhammad ruled in a dyarchy until the latter's death in 1203. Ghiyath al-Din, the senior partner, governed the western Ghurid regions from his capital at Firozkoh whereas Muhammad extended Ghurid rule eastwards, laying the foundation of Islamic rule in South Asia, which lasted after him for nearly half a millennium under evolving Muslim dynasties.

The Ghurid dynasty was a Persianate dynasty of presumably eastern Iranian Tajik origin, which ruled from the 8th-century in the region of Ghor, and became an Empire from 1175 to 1215. The Ghurids were centered in the hills of the Ghor region in the present-day central Afghanistan, where they initially started out as local chiefs. They gradually converted to Sunni Islam after the conquest of Ghor by the Ghaznavid ruler Mahmud of Ghazni in 1011. The Ghurids eventually overran the Ghaznavids when Muhammad of Ghor seized Lahore and expelled the Ghaznavids from their last stronghold.