Husam ad-Din Muhanna ibn Isa was the Arab lord of Palmyra and amir al-ʿarab under the Mamluk Sultanate. He served between 1284 and his death, but was dismissed and reinstated four times during this period. As the chieftain of the Al Fadl, a clan of the Tayy tribe, which dominated the Syrian Desert, Muhanna wielded considerable influence among the Bedouin. He was described by historian Amalia Levanoni as "the eldest and most senior amir" of the Al Fadl during his era.

Al Fadl were an Arab tribe that dominated the Syrian Desert and steppe during the Middle Ages, and whose modern-day descendants largely live in southern Syria and eastern Lebanon. The Al Fadl's progenitor, Fadl ibn Rabi'ah, was a descendant of the Banu Tayy through his ancestor, Mufarrij al-Jarrah. The tribe rose to prominence by assisting the Burids and Zengids against the Crusaders. The Ayyubids often appointed them to the office of Amir al-ʿarab, giving the Al Fadl emirs command over the Bedouin tribes of northern Syria. Their function was often to serve as auxiliary troops.