Mulegé is the northernmost municipality of the Mexican state of Baja California Sur. It is the largest municipality by area in Mexico, with an area of 33,092.20 km2. In the 2020 Census, it had a population of 64,022 inhabitants. Isla Natividad is part of the municipality.

Municipalities are the second-level administrative divisions of Mexico, where the first-level administrative division is the state. They should not be confused with cities or towns that may share the same name as they are distinct entities and do not share geographical boundaries. As of March 2024, there are 2,476 municipalities in Mexico, excluding the 16 boroughs of Mexico City.