Muleshoe is a city in Bailey County, Texas, United States. It was founded in 1913, when the Pecos and Northern Texas Railway built an 88-mile (142 km) line from Farwell, Texas, to Lubbock through northern Bailey County. In 1926, Muleshoe was incorporated. Its population was 5,158 at the 2010 census. The county seat of Bailey County, it is home to the National Mule Memorial.

Bailey County is a county located in the U.S. state of Texas. It is in West Texas and its county seat is Muleshoe. As of the 2020 census, its population was 6,904.