The Cathedral Church of Saint Mary in Murcia, commonly called the Cathedral of Murcia, is a Catholic church in the city of Murcia, Spain. It is the cathedral of the Roman Catholic Diocese of Cartagena.

Murcia is a city in south-eastern Spain, the capital and most populous city of the autonomous community of the Region of Murcia, and the seventh largest city in the country. It had a population of 460,349 inhabitants in 2021. The total population of the metropolitan area was 672,773 in 2020, covering an urban area of 1,230.9 km2. It is located on the Segura River, in the southeast of the Iberian Peninsula. It has a climate with hot summers, mild winters, and relatively low precipitation.