Murder in the Clouds is a 1934 American action film dealing with aviation. The film stars Lyle Talbot and Ann Dvorak, and is directed by D. Ross Lederman. Although standard formula "B" film fare, it was notable as the screenplay and original story was written by Dore Schary as a freelance writer, during one of his periods when he was fired from a more prestigious film job. Schary was a director, writer, producer and playwright who later became head of production at Metro-Goldwyn-Mayer, and eventually president of the studio. Equally important on Murder in the Clouds was the work of Elmer Dyer who had become a preeminent aviation cinematographer.

Lyle Florenz Talbot was an American stage, screen and television actor. His career in films spanned three decades, from 1931 to 1960, and he performed on a wide variety of television series from the early 1950s to the late 1980s. Among his notable roles on television was his portrayal of Ozzie Nelson's friend and neighbor Joe Randolph, a character he played for ten years on the ABC sitcom The Adventures of Ozzie and Harriet.