Balbir Singh Sodhi, a Sikh-American entrepreneur and franchisee in Mesa, Arizona, was murdered in a hate crime in the aftermath of the September 11 attacks. This was the first of several cases across the United States that were reported to the police as supposed acts of retaliation for the attacks. Balbir Singh Sodhi, who had a beard and wore a turban in accordance with his Sikh faith, was mistakenly profiled as an Arab Muslim and murdered by 42-year-old Frank Silva Roque, a Boeing aircraft mechanic at a local repair facility who held a criminal record for an attempted robbery in California. Roque had reportedly told friends that he was "going to go out and shoot some towel-heads" the day of the attacks. Roque was sentenced to death for first degree murder. He died in prison on May 11, 2022.

American Sikhs form the country's sixth-largest religious group. While the U.S. Census does not ask about religion, 70,697 Americans declared Sikh as their ethnicity in the 2020 census. The U.S. Census Bureau cites the 2008 American Religious Identification Survey's estimate of the adult Sikh American population at 78,000. The Pew Research Center estimated the Sikh American adult population to be 140,000 and the total population at 200,000 in 2012 while the World Religion Database at Boston University estimated the American Sikh population to be at 280,000 in 2012. Sikh organizations like the Sikh Coalition and American Sikh Congressional Caucus estimate the Sikh American population to be as high as 1,000,000, but do not provide any sources for these figures; 500,000 nevertheless remains the most cited Sikh American population size. With 1% of Asian Americans being Sikh, and 90.7% of Sikh Americans being Asian American, the American Sikh population can be estimated at around 200,000–300,000 in 2021. The largest Sikh populations in the U.S. are found in California (52%), New York (11%), and Washington (6%).