The Murray-Sunset National Park is the second largest national park in Victoria, Australia, located in the Mallee district in the northwestern corner of the state, bordering South Australia. The 633,000-hectare (1,560,000-acre) national park is situated approximately 440 kilometres (270 mi) northwest of Melbourne and was proclaimed in 1991. It is in the northwestern corner of the state, bordering South Australia to the west and the Murray River to the north. The Sturt Highway passes through the northern part of the park, but most of the park is in the remote area between the Sturt Highway and the Mallee Highway, west of the Calder Highway.

The Mallee is a sub-region of Loddon Mallee covering the most north-westerly part of Victoria, Australia and is bounded by the South Australian and New South Wales borders. Definitions of the south-eastern boundary vary, however, all are based on the historic Victorian distribution of mallee eucalypts. These trees dominate the surviving vegetation through most of Mallee,. Its biggest settlements are Mildura and Swan Hill.