Murrough MacDermod O'Brien, 1st Earl of Inchiquin, was an Irish nobleman and soldier, who came from one of the most powerful families in Munster. Known as Murchadh na dTóiteán, he initially trained for war in the Spanish service. He accompanied the Earl of Strafford into Leinster on the outbreak of the Irish Rebellion of 1641 and was appointed governor of Munster in 1642. He had some small success, but was hampered by lack of funds and he was outwitted by the Irish leader, Viscount Muskerry, at Cappoquin and Lismore. His forces dispersed at the truce of 1643.

The Irish Rebellion of 1641 was an uprising by Catholics in Ireland, whose demands included an end to anti-Catholic discrimination, greater Irish self-governance, and return of confiscated Catholic lands. Its timing was partially driven by the dispute between Charles I and his opponents—the English Parliamentarians and Scottish Covenanters—which the rebels feared would lead to an invasion and further anti-Catholic measures. Beginning as an attempted coup d'état by Catholic gentry and military officers, it developed into a widespread rebellion and ethnic conflict with English and Scottish Protestant settlers. It led to the 1641–1653 Irish Confederate Wars, part of the Wars of the Three Kingdoms, with up to 20% of the Irish population becoming casualties.