The Murwillumbah railway line is a mostly disused railway line in far north-eastern Northern Rivers New South Wales, Australia. The line ran from Casino to Lismore, Byron Bay, Mullumbimby and Murwillumbah, opening in 1894. It is one of only two branches off the North Coast line,. Train services to the region ceased in May 2004. The line from Casino to Bentley and Murwillumbah to Crabbes Creek was formally closed on 23 September 2020 to facilitate the construction of a rail trail.

Northern Rivers is the most northeasterly region of the Australian state of New South Wales, located between 590 and 820 kilometres north of the state capital, Sydney, and encompasses the catchments and fertile valleys of the Clarence, Richmond, and Tweed rivers. It extends from Tweed Heads in the north to the southern extent of the Clarence river catchment which lies between Grafton and Coffs Harbour, and includes the main towns of Tweed Heads, Byron Bay, Ballina, Kyogle, Lismore, Casino and Grafton. At its most northern point, the region is 102 kilometres (63 mi) south-southeast of the Queensland capital, Brisbane.