The Musée des Beaux-Arts de Strasbourg is the old masters paintings collection of the city of Strasbourg, located in the Alsace region of France. The museum is housed in the first and second floors of the baroque Palais Rohan since 1898. The museum displays works by non-Upper Rhenish artists from between the 14th century and 1871 and by Upper Rhenish artist from between 1681 and 1871. The museum owned 1,934 works as of 31 December 2015, this number has substantially increased since. The old masters from the upper-Rhenish area until 1681 are exhibited in the neighboring Musée de l’Œuvre Notre-Dame.

The Palais Rohan in Strasbourg is the former residence of the prince-bishops and cardinals of the House of Rohan, an ancient French noble family originally from Brittany. It is a major architectural, historical, and cultural landmark in the city. It was built next to Strasbourg Cathedral in the 1730s, from designs by Robert de Cotte, and is considered a masterpiece of French Baroque architecture. Since its completion in 1742, the palace has hosted a number of French monarchs such as Louis XV, Marie Antoinette, Napoleon and Joséphine, and Charles X.