Musashi-Sakai Station is an interchange passenger railway station located in the city of Musashino, Tokyo, Japan, operated by East Japan Railway Company and the private railway company, Seibu Railway.

Musashino is a city located in the western portion of Tokyo Metropolis, Japan. As of 1 February 2024, the city had an estimated population of 147,754 in 78,614 households, and a population density of 13,000 persons per km2. The total area of the city is 10.98 square kilometres (4.24 sq mi). Based on the 2019 survey by SUUMO, the Kichijoji neighborhood of Musashino was the third most desirable place to live in central Japan.