Muscatine High School is a four-year comprehensive public high school in Muscatine, Iowa. The school is part of the Muscatine Community School District. Located approximately one mile east of U.S. Highway 61 in Muscatine, Muscatine High School teaches students from the city and adjacent rural areas.

Muscatine is a city in Muscatine County, Iowa, United States. The population was 23,797 at the time of the 2020 census, an increase from 22,697 in 2000. The county seat of Muscatine County, it is located along the Mississippi River. The local business association states that the name Muscatine is not used by any other community.