The Muscle Shoals Rhythm Section is a group of American session musicians based in the northern Alabama town of Muscle Shoals. One of the most prominent American studio house bands from the 1960s to the 1980s, these musicians, individually or as a group, have been associated with more than 500 recordings, including 75 gold and platinum hits. They were masters at creating a southern combination of R&B, soul and country music known as the "Muscle Shoals sound" to back up black artists, who were often in disbelief to learn that the studio musicians were white. Over the years from 1962 to 1969, there have been two successive groups under the name "Muscle Shoals Rhythm Section" and the common factor in the two was an association with Rick Hall at FAME Studios in Muscle Shoals.

Aretha Louise Franklin was an American singer, songwriter and pianist. Referred to as the "Queen of Soul", Rolling Stone twice named her as the greatest singer of all time.