The Museo Nacional Centro de Arte Reina Sofía is Spain's national museum of 20th-century art. The museum was officially inaugurated on September 10, 1992, and is named for Queen Sofía. It is located in Madrid, near the Atocha train and metro stations, at the southern end of the so-called Golden Triangle of Art.

Sofía is a member of the Spanish royal family who was Queen of Spain from 1975 to 2014 as the wife of King Juan Carlos I. She is the first child of Paul of Greece and Frederica of Hanover.