The music of Louisiana can be divided into three general regions: rural south Louisiana, home to Creole Zydeco and Old French, New Orleans, and north Louisiana. The region in and around Greater New Orleans has a unique musical heritage tied to Dixieland jazz, blues, and Afro-Caribbean rhythms. The music of the northern portion of the state starting at Baton Rouge and reaching Shreveport has similarities to that of the rest of the US South.

Zydeco is a music genre that was created in rural Southwest Louisiana by Afro-Americans of Creole heritage. It blends blues and rhythm and blues with music indigenous to the Louisiana Creoles such as la la and juré, using the French accordion and a creole washboard instrument called the frottoir.