Music was ubiquitous throughout Mesopotamian history, playing important roles in both religious and secular contexts. Mesopotamia is of particular interest to scholars because evidence from the region—which includes artifacts, artistic depictions, and written records—places it among the earliest well-documented cultures in the history of music. The discovery of a bone wind instrument dating to the 5th millennium BCE provides the earliest evidence of music culture in Mesopotamia; depictions of music and musicians appear in the 4th millennium BCE; and later, in the city of Uruk, the pictograms for ‘harp’ and ‘musician’ are present among the earliest known examples of writing.

Mesopotamian religion refers to the religious beliefs and practices of the civilizations of ancient Mesopotamia, particularly Sumer, Akkad, Assyria and Babylonia between circa 6000 BC and 400 AD. The religious development of Mesopotamia and Mesopotamian culture in general, especially in the south, were not particularly influenced by the movements of the various peoples into and throughout the area. Rather, Mesopotamian religion was a consistent and coherent tradition, which adapted to the internal needs of its adherents over millennia of development.