The Muslim conquest of the Levant, or Arab conquest of Syria, was a 634–638 CE invasion of Byzantine Syria by the Rashidun Caliphate. A part of the wider Arab-Byzantine Wars, the Levant was brought under Arab Muslim rule and developed into the provincial region of Bilad al-Sham. Clashes between the Arabs and Byzantines on the southern Levantine borders of the Byzantine Empire had occurred during the lifetime of Muhammad, with the Battle of Muʿtah in 629 CE. However, the actual conquest did not begin until 634, two years after Muhammad's death. It was led by the first two Rashidun caliphs who succeeded Muhammad: Abu Bakr and Umar ibn al-Khattab. During this time, Khalid ibn al-Walid was the most important leader of the Rashidun army.

The Byzantine Empire, also referred to as the Eastern Roman Empire, was the continuation of the Roman Empire centered in Constantinople during Late Antiquity and the Middle Ages. The eastern half of the Empire survived the conditions that caused the fall of the West in the 5th century AD, and continued to exist until the fall of Constantinople to the Ottoman Empire in 1453. During most of its existence, the empire remained the most powerful economic, cultural, and military force in the Mediterranean world. The term "Byzantine Empire" was only coined following the empire's demise; its citizens referred to the polity as the "Roman Empire" and to themselves as "Romans". Due to the imperial seat's move from Rome to Byzantium, the adoption of state Christianity, and the predominance of Greek instead of Latin, modern historians continue to make a distinction between the earlier Roman Empire and the later Byzantine Empire.