Mutant Enemy Productions is a production company that was created in 1996 by Joss Whedon to produce Buffy the Vampire Slayer. The company also produced the Buffy spin-off, Angel, and his two short-lived science fiction series, the space Western Firefly and his high-concept Dollhouse, produced by 20th Century Fox Television. Mutant Enemy also produced the internet series Dr. Horrible's Sing-Along Blog and the film The Cabin in the Woods. Mutant Enemy produced the superhero series Agents of S.H.I.E.L.D. along with ABC Studios and Marvel Television. Most recently, Mutant Enemy produced the supernatural fiction series The Nevers for HBO.

Joseph Hill Whedon is an American screenwriter, director, producer, comic book writer, and composer. He is the founder of Mutant Enemy Productions, co-founder of Bellwether Pictures, and is best known as the creator of several television series: the supernatural drama Buffy the Vampire Slayer (1997–2003) and its spinoff Angel (1999–2004), the short-lived space Western Firefly (2002), the Internet musical miniseries Dr. Horrible's Sing-Along Blog (2008), the science fiction drama Dollhouse (2009–2010), the Marvel Cinematic Universe series Agents of S.H.I.E.L.D. (2013–2020), and the science fiction drama The Nevers (2021).