Mutant Enemy Productions is a production company that was created in 1996 by Joss Whedon to produce Buffy the Vampire Slayer. The company also produced the Buffy spin-off, Angel, and his two short-lived science fiction series, the space Western Firefly and his high-concept Dollhouse, produced by 20th Century Fox Television. Mutant Enemy also produced the internet series Dr. Horrible's Sing-Along Blog and the film The Cabin in the Woods. Mutant Enemy produced the superhero series Agents of S.H.I.E.L.D. along with ABC Studios and Marvel Television. Most recently, Mutant Enemy produced the supernatural fiction series The Nevers for HBO.

Marvel's Agents of S.H.I.E.L.D. is an American television series created by Joss Whedon, Jed Whedon, and Maurissa Tancharoen for ABC based on the Marvel Comics organization S.H.I.E.L.D., a peacekeeping and spy agency in a world of superheroes. The series was the first to be set in the Marvel Cinematic Universe (MCU), and it acknowledges the continuity of the franchise's films and other television series. It was produced by ABC Studios, Marvel Television, and Mutant Enemy Productions, with Jed Whedon, Maurissa Tancharoen, and Jeffrey Bell serving as showrunners.