The first series of BBC family sitcom My Family originally aired between 19 September and 7 November 2000. The first episode of the series, and the pilot episode, is entitled "The Serpent's Tooth". All eight episodes in the first series are thirty minutes long. The first episode introduces the five main characters that regularly appear in the series: Robert Lindsay, who plays Ben, Zoë Wanamaker, who plays Susan, Kris Marshall, who plays Nick, Daniela Denby-Ashe, who plays Janey, and Gabriel Thomson, who plays Michael. A further regular member of the cast is Brigitte, played by Daisy Donovan, who appears in nearly every episode of the series. The series was produced by Rude Boy Productions, a company that produces comedies created by Fred Barron. The series was filmed at Pinewood Studios in Buckinghamshire, with a live studio audience.

My Family is a British sitcom created and initially co-written by Fred Barron, which was produced by DLT Entertainment and Rude Boy Productions, and broadcast by BBC One for eleven series between 2000 and 2011, with Christmas specials broadcast from 2002 onwards. My Family was voted 24th in the BBC's "Britain's Best Sitcom" in 2004 and was the most watched sitcom in the United Kingdom in 2008. As of 2011, it is one of only twelve British sitcoms to pass the 100-episode mark. In April 2020, BBC One began airing the series from the first episode in an 8 pm slot on Friday nights; along with this all 11 series were made available on BBC iPlayer.