My Sister Eileen is a 1942 American comedy film directed by Alexander Hall and starring Rosalind Russell, Brian Aherne and Janet Blair. The screenplay by Joseph A. Fields and Jerome Chodorov is based on their 1940 play of the same title, which was inspired by a series of autobiographical short stories by Ruth McKenney originally published in The New Yorker. The supporting cast features George Tobias, Allyn Joslyn, Grant Mitchell, Gordon Jones and, in a cameo appearance at the end, The Three Stooges.

Catherine Rosalind Russell was an American actress, comedian, screenwriter, and singer, known for her role as fast-talking newspaper reporter Hildy Johnson in the Howard Hawks screwball comedy His Girl Friday (1940), opposite Cary Grant, as well as for her portrayals of Mame Dennis in the 1956 stage and 1958 film adaptations of Auntie Mame, and Rose in Gypsy (1962). A noted comedienne, she won all five Golden Globes for which she was nominated. Russell won the Tony Award for Best Actress in a Musical in 1953 for her portrayal of Ruth in the Broadway show Wonderful Town. She was nominated for the Academy Award for Best Actress four times during her career before being awarded a Jean Hersholt Humanitarian Award in 1973.