The Myasishchev M-50 is a Soviet prototype four-jet engine supersonic strategic bomber which never attained service. Only one flightworthy prototype was built, which was first flown in October 1959. The M-50 was constructed by the Myasishchev design bureau.

V. M. Myasishchev Experimental Design Bureau or OKB-23, founded in 1951 by MGB UdSSR Vladimir Myasishchev, was one of the chief Soviet aerospace design bureaus until its dissolution in 1960. Vladimir Myasishchev went on to head TsAGI. In 1967, Myasishchev left TsAGI and recreated his bureau, which still exists to this day. The bureau prefix was "M." As of 2003, its workforce is estimated at approx­imately one thousand. Myasishchev and NPO Molniya intend to use the V-MT or M-55 as launch vehicle for sub-orbital spaceflight.