Mystery of the Double Cross is a 1917 film and one of the few American silent action film serials to survive in complete form. It was directed by Louis J. Gasnier and William Parke, from a story written by Gilson Willets, produced by the Astra Film Corporation and released in weekly chapters by Pathé, starting March 18, 1917.

Louis Joseph Gasnier was a French-American film director, producer, screenwriter and stage actor. A cinema pioneer, Gasnier shepherded the early career of comedian Max Linder, co-directed the enormously successful film serial The Perils of Pauline (1914) and capped his output with the notorious low-budget exploitation film Reefer Madness (1936) which was both a critical and box office failure.