Mzuzu is the capital of Malawi's Northern Region and is the third largest city by population in Malawi. The city has 221,272 residents and 20,000 commuters with about 1.7 million people in its metropolitan area. It is situated in Mzimba District. Mzuzu lies in a gap in the Viphya Mountains, and the agricultural region surrounding the city specializes in tea, rubber and coffee cultivation. The Viphya Plantation south of the city is the largest man-made forest in Africa, and the Lunyangwa and Kaning'ina forest preserves are east of the city. The town is located inside Mzimba District.

Malawi, officially the Republic of Malawi and formerly known as Nyasaland, is a landlocked country in Southeastern Africa. It is bordered by Zambia to the west, Tanzania to the north and northeast, and Mozambique to the east, south and southwest. Malawi spans over 118,484 km2 (45,747 sq mi) and has an estimated population of 19,431,566. Malawi's capital and largest city is Lilongwe. Its second-largest is Blantyre, its third-largest is Mzuzu and its fourth-largest is its former capital, Zomba. It was the first capital city of Malawi before being changed to Lilongwe.