The N52 road is a national secondary road in Ireland. It links the M7 motorway from just south of Nenagh, County Tipperary to the M1 motorway north of Dundalk in County Louth. The route forms a connection between the north east of Ireland and the mid west traversing the midlands. It interchanges with the M6 at Kilbeggan and at Tyrrellspass, the N4 at Mullingar, the N3 at Kells, and the N2 at Ardee before continuing towards Dundalk.

A national secondary road is a category of road in Ireland. These roads form an important part of the national route network but are secondary to the main arterial routes which are classified as national primary roads. National secondary roads are designated with route numbers higher than those used for primary roads, but with the same "N" prefix. Routes N51 and higher are all national secondary roads.