The National Aeronautics and Space Administration is an independent agency of the U.S. federal government responsible for the civil space program, aeronautics research, and space research. Established in 1958, it succeeded the National Advisory Committee for Aeronautics (NACA) to give the U.S. space development effort a distinct civilian orientation, emphasizing peaceful applications in space science. It has since led most of America's space exploration programs, including Project Mercury, Project Gemini, the 1968–1972 Apollo Moon landing missions, the Skylab space station, and the Space Shuttle. Currently, NASA supports the International Space Station along with the Commercial Crew Program, and oversees the development of the Orion spacecraft and the Space Launch System for the lunar Artemis program.

In the United States government, independent agencies are agencies that exist outside the federal executive departments and the Executive Office of the President. In a narrower sense, the term refers only to those independent agencies that, while considered part of the executive branch, have regulatory or rulemaking authority and are insulated from presidential control, usually because the president's power to dismiss the agency head or a member is limited.