The National Football League Kickoff Game, along with related festivities, marks the official start of the National Football League (NFL) regular season. A single game is held, preceded by a concert and other ceremonies. This first game of the season is usually scheduled for the Thursday following Labor Day. An exception was made in 2012, when the game was moved to Wednesday to prevent conflicts with the acceptance speech of the Democratic National Convention. Although the Kickoff Game is typically played on Thursday night, the league treats it separately from the Thursday Night Football games during the rest of the season.

The 2012 Democratic National Convention was a gathering, held from September 4–6, 2012, at the Time Warner Cable Arena in Charlotte, North Carolina, in which delegates of the Democratic Party nominated President Barack Obama and Vice President Joe Biden for reelection, in the 2012 United States national election.