The NFL Top 100 Players of 2016 was the sixth season in the series. It aired on May 4, 2016. It ended with reigning NFL MVP Cam Newton being ranked #1. The Kansas City Chiefs had the most players selected with nine, while the Chicago Bears were the only team with no selections.

Adrian Lewis Peterson is an American former football running back who played fifteen seasons in the National Football League (NFL). He is widely considered to be one of the greatest running backs in football history. He played college football for the Oklahoma Sooners, setting the freshman rushing record with 1,925 yards in 2004. Named a unanimous All-American that year, he became the first freshman to finish as a runner-up in the Heisman Trophy balloting. Peterson finished his college career as the Sooners' third all-time leading rusher.