NFL Top 100 Players of 2021 is the eleventh season in the NFL Top 100 series. It premiered on August 15, 2021, and concluded on August 28, 2021. Kansas City Chiefs quarterback Patrick Mahomes was named the number one player.

The NFL Top 100 is an annual television series counting down the top one hundred players in the National Football League (NFL), as chosen by fellow NFL players. The rankings are based on an off-season poll organized by the NFL, where players vote on their peers based on their performance for the recent NFL season. Only players that are not retired in the next season are eligible for consideration.