NGC 5053 is the New General Catalogue designation for a globular cluster in the northern constellation of Coma Berenices. It was discovered by German-British astronomer William Herschel on March 14, 1784 and cataloged as VI-7. In his abbreviated notation, he described it as, "an extremely faint cluster of extremely small stars with resolvable nebula 8 or 10′ diameter, verified by a power of 240, beyond doubt". Danish-Irish astronomer John Louis Emil Dreyer reported in 1888 that the cluster appeared, "very faint, pretty large, irregular round shape, growing very gradually brighter at the middle".

Coma Berenices is an ancient asterism in the northern sky, which has been defined as one of the 88 modern constellations. It is in the direction of the fourth galactic quadrant, between Leo and Boötes, and it is visible in both hemispheres. Its name means "Berenice's Hair" in Latin and refers to Queen Berenice II of Egypt, who sacrificed her long hair as a votive offering. It was introduced to Western astronomy during the third century BC by Conon of Samos and was further corroborated as a constellation by Gerardus Mercator and Tycho Brahe. It is the only modern constellation named for a historic person.