The NHS Nightingale Hospital Birmingham was the second of the temporary NHS Nightingale Hospitals set up by NHS England to help to deal with the COVID-19 pandemic. It was constructed inside the National Exhibition Centre, Solihull, and opened on 16 April 2020. It cost £66.4 million to set up and was the most expensive of all the Nightingale temporary hospitals. On 1 April 2021 the hospital closed without ever treating a patient.

The National Exhibition Centre (NEC) is an exhibition centre located in Marston Green, England, near to Birmingham and Solihull. It is near junction 6 of the M42 motorway, and is adjacent to Birmingham Airport and Birmingham International railway station. It was opened by Queen Elizabeth II in 1976.